Selenocysteine antagonizes oxygen glucose deprivation-induced damage to hippocampal neurons
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چکیده
منابع مشابه
Tanshinone IIA pretreatment attenuates oxygen-glucose deprivation induced hippocampal neurons damage
Objective: Tanshinone IIA (Tan IIA) has been used in treatment of ischemic stroke in China. This study was designed to investigate the underlying neuroprotective mechanism of Tan IIA pretreatment in primary cultured rat hippocampal neurons incurred oxygen-glucose deprivation (OGD). Method: Hippocampal neurons was prepared from E18 embryonic rats and identified by immunocytochemical staining. Af...
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Hypoxic injuries during fetal distress have been shown to cause reduced expression of microRNA-27a (miR-27a), which regulates sensitivity of cortical neurons to apoptosis. We hypothesized that miR-27a overexpression attenuates hypoxia- and ischemia-induced neuronal apoptosis by regulating FOXO1, an important transcription factor for regulating the oxidative stress response. miR-27a mimic was tr...
متن کاملMicroRNA-132 protects hippocampal neurons against oxygen-glucose deprivation–induced apoptosis
Hypoxic-ischemic brain injury (HIBI) results in death or long-term neurologic impairment in both adults and children. In this study, we investigated the effects of microRNA-132 (miR-132) dysregulation on oxygen-glucose deprivation (OGD)-induced apoptosis in fetal rat hippocampal neurons, in order to reveal the therapeutic potential of miR-132 on HIBI. MiR-132 dysregulation was induced prior to ...
متن کاملTetramethylpyrazine Protects Neurons from Oxygen-Glucose Deprivation-Induced Death
BACKGROUND To explore the theoretical basis for protecting the brain from ischemic stroke with tetramethylpyrazine, we studied whether and how tetramethylpyrazine could protect neurons against the oxygen-glucose deprivation (OGD)-induced death and whether transient receptor potential cation channel, subfamily C, member 6 (TRPC6) was involved. MATERIAL AND METHODS Primary rat cortical neurons we...
متن کاملAge-related susceptibility to oxygen and glucose deprivation damage in rat hippocampal slices.
Aging is an important risk factor for stroke. We evaluated the effects of aging on cell susceptibility to oxygen and glucose deprivation (OGD) in slices of the hippocampus from Wistar rats aged 2, 11 and 24 months. Lactate dehydrogenase (LDH) released to the incubation media and free radical content were markedly increased in the 24-month group submitted to OGD. These results confirm that hippo...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2018
ISSN: 1673-5374
DOI: 10.4103/1673-5374.235300